MCB3025F - Structural & Chemical Biology

Course Outline:

This course addresses how modern techniques of structural and chemical biology are being used to solve biological problems. It draws on multiple aspects of macromolecular biochemistry including nucleic acid structure and interactions, signalling proteins and membrane proteins, and demonstrates how this knowledge can be used in drug discovery and protein design in biotechnology. Topics include: mechanisms of reversible and irreversible enzyme inhibitors, ligand binding, protein folding, molecular basis for protein function, regulation of protein activity, cell signalling and proteomics.